Purolite™ A500TLOHPlus

Innovative High pH Elution Technology

The unique ligand design allows for elution at a wider range of pH (3 - 5) when compared to conventional protein A chromatography without impacting yield, purity or elution volumes.

Alkaline Stability

Sodium hydroxide (NaOH) exhibits high efficiency in removing bound proteins, nucleic acids, and lipids from bioprocess resins, alleviating the risk of fouling on heavily burdened Protein A columns. Purolite Jetted A50 HipH maintains excellent capacity after exposure to 0.1 M NaOH for 120 hours, facilitating efficient CIP and longer resin lifetime.

Dynamic Binding Capacity

The uniform jetted bead maintains high mass transfer and high capacity even at low residence times. Purolite Jetted A50 HipH shows comparable performance for polyclonal IgG capacity to Purolite Jetted A50.