SCIENTIFIC POSTER

Process intensification in mAb capture using an innovative, high capacity Protein A resin in batch operation

The cost of Protein A resins is one of the major contributors to the cost of goods sold (COGS) in the manufacturing of mAbs, especially at the clinical stages. Innovative approaches such as intensified batch processing and continuous chromatography help to alleviate this burden and bring down the COGS by increasing the productivity (g purified mAb/L resin/hour), reducing facility footprint and buffer consumption without negatively impacting the product quality.

In this study, we compare the latest generation Protein A resin, Purolite™ Praesto™ Jetted A50, a jetted agarose bead, against the market-leading batch emulsified protein A resin.