Purolite Praesto™ Jetted A50 HipH

Overview

The unique properties of Purolite Praesto Jetted A50 HipH address challenges in eluting pH-sensitive mAbs and Fc-containing proteins, which can become unstable at pH levels typically used for elution with other protein A resins (3 – 3.5).
 

This resin provides alkaline stability, capacity of 60 g/L for polyclonal human IgG and elution up to pH 5. This creates a wider operational window for your protein A step, facilitating rapid process development and processing of all Fc-containing molecules by:

• Enabling use of a classic antibody purification platform
• Retaining the unique specificity of protein A for high recovery and excellent productivity
• Minimizing impact on facility fit with comparable elution volumes and buffer usage
• Lowering levels of post-protein A contaminants, reducing polishing challenges and driving process robustness
   

Jetting Technology

• Faster mass transfer kinetics
• Reduced column packing failures
• Improved resolution
• Higher flow velocities
• Longer lifetime