APPLICATION NOTE

Impact of Tip-based Systems and Jetting Technology on High Throughput Process Development

High‑throughput process development (HTPD) continues to transform modern bioprocessing by enabling rapid resin screening, efficient optimization, and faster progression from development to manufacturing. Tip‑based systems such as IMCStips® allow researchers to mix loose resin and sample directly within a pipette‑tip format, supporting automated workflows of up to 96 tips at once. This approach delivers batch‑like binding performance with improved speed and reproducibility. 

Purolite™ resins manufactured with advanced jetting technology offer enhanced mass‑transfer properties, narrow bead size distribution, and improved dynamic binding capacity (DBC), making them especially effective for tip‑based HTPD applications. Studies comparing Praesto™ Jetted A50 to other leading Protein A resins show superior binding efficiency, balanced fast and slow binding kinetics, and higher yields across a wide range of protein concentrations. 

By integrating tip‑based workflows with high‑performance jetted resins, bioprocess development teams can reduce cycle times, increase binding efficiency, and streamline their optimization strategies - ultimately accelerating timelines while maintaining consistent product quality.