CASE STUDY

Solve Downstream Purification Challenges with BPAL

See how Ecolab’s network of Bioprocessing Applications Laboratories (BPAL) combines specialized expertise, advanced development capabilities, and practical problem-solving to help overcome complex purification challenges.

When a biopharmaceutical organization encountered significant aggregation and low recovery in a monoclonal antibody purification process, Ecolab’s BPAL team developed a tailored downstream strategy designed around the needs of the molecule.
Utilizing high-throughput screening, chromatography development, and lab-scale confirmation, the team identified an optimized three-step purification workflow that improved recovery while dramatically reducing aggregation.

Explore the BPAL Case Study

See how BPAL can act as an extension of your process development team, providing the expertise, equipment, and experimental capacity needed to investigate challenging downstream purification problems.

In this case study, discover how BPAL helped:

• Increase product recovery by 41%
• Enable greater than 99% monomer purity
• Reduce process complexity and rework risk
• Develop a more robust purification strategy tailored to the molecule

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APPLICATION NOTE

Design and Optimization of a Three-Step Monoclonal Antibody Purification Workflow to Improve Yield and Reduce Aggregation

Explore the development of an optimized three-step purification workflow for an aggregation-prone monoclonal antibody. The application note examines Protein A capture development, anion and cation exchange polishing, high-throughput screening, and optimization of the complete purification process.

See how Praesto™ Jetted A50 HipH, Praesto™ Q65, and Praesto™ SP65 resins were used to address key purification challenges, including:

• Improving overall process yield
• Significantly reducing aggregate levels
• Achieving high final monomer purity
• Effectively clearing residual HCP and DNA impurities
• Download the application note to see the complete workflow, optimization approach, and final performance results.

Download the Application Note

Affinity Resin Selector

mAb & protein purification

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Affinity Chromatography Resins

IEX Chromatography Resins

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Adsorbents

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Resina Catiónica Debilmente ácida

Resina Aniónica Debilmente Básica

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