Purolite Praesto 70 CH1

Request a Quote

Addressing Impurity Challenges in Bispecific Purification

Antibody variants used in the development of therapeutic medicines have expanded, bringing innovative therapies to patients. However, traditional purification procedures have proven inefficient.

Purolite 70 CH1 is engineered to purify specialized mAbs, including bispecifics and antibody fragments, supporting the diversification of therapeutic molecules and clinical pipelines.

Offering up to twice the dynamic binding capacity of established CH1 resins, improving process economics in complex purification procedures.

Compared to established CH1 resins, Purolite 70 CH1 offers improved alkaline stability, allowing for the adoption of standard CIP protocols.
 

Purolite™ Chromatography Resins

Purolite 70 CH1 is manufactured using patented Jetting technology, ensuring uniform particle size for enhanced quality and performance. Jetting manufacturing supports sustainability through reduced use of harmful solvents and water usage.

Compared to traditional methods, Jetting accelerates time to market with fewer production steps.

Features

High capacity 70 μm bead

Alkaline stable up to 0.1 M NaOH

High dynamic binding capacity up to 50 g/L

Product Data

NaOH Stability

Relative binding capacity of Purolite 70 CH1 after 0.1 M NaOH exposure.

Praesto 70 CH1 offers improved caustic stability compared to established CH1 resins, allowing the adoption of standard 0.1M NaOH CIP protocols.
Dynamic Binding Capacity
Capacity data for an IgG1 subclass monoclonal antibody on Praesto 70 CH1 at 3, 4.8, 6, and 10-minute residence time.

Purolite 70 CH1 offers higher binding capacity than any established CH1 resin, delivering favorable process economics for bispecifics and fusion proteins.

Resources

Purolite Praesto 70 CH1 Datafile

Download

Laboratory Scale Column Packing Instructions

Download

Pilot Scale Column Packing Instructions

Download

Purolite Praesto 70 CH1 IFU

Download

Purolite Praesto™ 70 CH1

Typical Physical & Chemical Properties

Matrix

Highly cross-linked agarose

Dynamic binding capacity

40 g/L mAb (IgG1) Fab* at 6 minute residence time

Average Particle Size

70 µm

Pressure/flow specifications

400 cm/h at 1.8 bar (30 x 20 cm)

Faixa de Tamanho de Esferas

> 95% between 43-122 µm

pH Stability (Working Range)

2 - 13

pH Stability, CIP (Short Term)

2 - 13

Armazenamento Recomendado

2 - 8 °C in 20% ethanol

Related Content

Scientific Poster
The Development of Next Generation Affinity Resins

Download Now >
Webinar
Next-Generation for Affinity Chromatography

Watch Now > 
Ecolab Step-by-Step Column Packing Video Instructions


Watch Now >