DurA Cycle A50
Driving innovation and performance while
reducing cost of goods.
With 40 years of manufacturing expertise and 30 years of regulatory experience, we supply leading separation, purification and extraction technologies to support chromatography and biocatalysis applications in healthcare and life sciences.
(目前只有英文)
Up to 70 mg/ml mAb and up to 80 mg/ml hIgG
Alkaline Stable. At over 100 hours exposure (NaOH) to 0.1 M NaOH
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The only manufacturer of uniform particle size agarose resins
Excellent Pressure Flow Properties
The uniform particle size and highly cross-linked agarose base bead provides increased surface area without severely impacting pressure flow properties. Purolite Praesto Jetted A50 has excellent flow properties, with up to 200 cm/h achievable in a standard mAb platform process. This has been verified in process scale columns.
Alkaline Stability
Sodium hydroxide exhibits high efficiency in removing bound proteins, nucleic acids, and lipids from bioprocess resins, alleviating the risk of fouling on heavily burdened Protein A columns. Purolite Praesto Jetted A50 is alkaline stable for over 100 hours of exposure to 0.1 M NaOH, and over 30 hours of exposure to 0.5 M NaOH.
Dynamic Binding Capacity
Purolite Praesto Jetted A50 exhibits high dynamic binding capacities for conventional monoclonal antibodies, up to 70 g/L at a 10-minute residence time. Patented Jetting technology, coupled with the latest Protein A technology, allows for high capacity at even low residence times. The resin is uniquely suited to address the demands of modern bioprocessing, from high-titre cell cultures to continuous chromatography formats.
聚合物结构
Highly cross linked agarose
Appearance
Spherical, uniform size beads supplied in 20% ethanol slurry. On request 2% benzylalcohol
功能基团
Protein A
Dynamic binding capacity
Up to 70 mg mAb/ml resin
Up to 80 mg hIgG/ml resin
(10 minute residence time)
Average Particle Size
50 µm
Particle size range (micron)
>95% between 35-90 µm
Pressure/Flow specifications
Up to 200 cm/h (30 x 20 cm)
pH stability, working range
3 - 12
pH stability, CIP (short term)
2 - 13
Recommended storage
2 - 8 °C in 20% ethanol / 2% benzyl alcohol. Shipped in 20% ethanol / 2 % benzyl alcohol on request.
