Overview
The unique properties of Purolite Praesto Jetted A50 HipH address challenges in eluting pH-sensitive mAbs and Fc-containing proteins, which can become unstable at pH levels typically used for elution with other protein A resins (3 – 3.5).
This resin provides alkaline stability, capacity of 60 g/L for polyclonal human IgG and elution up to pH 5. This creates a wider operational window for your protein A step, facilitating rapid process development and processing of all Fc-containing molecules by:
- Enabling use of a classic antibody purification platform
- Retaining the unique specificity of protein A for high recovery and excellent productivity
- Minimizing impact on facility fit with comparable elution volumes and buffer usage
- Lowering levels of post-protein A contaminants, reducing polishing challenges and driving process robustness
Jetting Technology
Purolite Praesto chromatography resins contain the only uniform agarose beads on the market. This gives Purolite Praesto resins unique performance benefits when utilized in process, such as:
- Faster mass transfer kinetics
- Reduced column packing failures
- Improved resolution
- Higher flow velocities
- Longer lifetime
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