Overview
Literature

Principal Applications

  • Protein purification (20-500 kDa)
  • MAb Purification

Advantages

  • Excellent dynamic binding capacities for high-productivity and scalability
  • Excellent pressure/flow performance
  • High resolution/selectivity
  • Excellent chemical and physical stability
  • Secure, validated supply and regulatory support

Regulatory Approvals

  • Manufactured under GMP conditions

Typical Physical & Chemical Characteristics:

Matrix Cross-linked agarose
Functional group CH2CH2CH2SO3 -
Ionic capacity - medium 0.11 - 0.18 mmol H⁺/ml
Average particle size (d50ᵥ), μm 90 µm
Flow velocity Up to 550 cm/h (20 x 20 cm)
Binding Capacity mg/mL Resin at 6’ Residence Time ≥ 50 mg lgG/ml
Operating pH Stability (Short Term) 3 - 14
Operating pH Stability (Long-Term) 4 - 12
Working Temperature 4 - 30 °C
Chemical stability All commonly used aqueous buffers. 1M NaOH, 8M urea, 6M guanidine hydrochloride, 30% isopropanol and 70% ethanol
Avoid Oxidising agents, cationic detergents
Recommended storage 20% ethanol, 0.2 M sodium acetate, 4–30 °C