Bioprocessing

Accelerate your biologic drug development with Praesto® 
chromatography resins.

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Monoclonal antibody and recombinant protein purification
Monoclonal antibody and recombinant protein purification
Products Jetting Technology Security of Supply Technical Support

Core Technologies

As the global leader in resin technology, we develop and manufacture small beads that are used in the most regulated industries in the world to separate, remove or recover very specific elements and compounds.

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Product Types
Product Types
Adsorbents
Adsorbents
Overview Adsorbents for Enzyme Immobilization Adsorbents for Gases and Organic Vapors Adsorbents of Organic Pollutants Citrus Juice Debittering Corn Sweetener Refining Inorganic Salt Separation Using Adsorbents Patulin Removal Polyphenol Recovery
Catalyst Chelation Resins Chromatographic Separation Resins Fine Mesh Resins Inert Spacer Resins Mixed Bed Resins
Mixed Bed Resins
Overview Mixed Bed Nuclear Mixed Bed Ultrapure Water
Strong Acid Cation Resin Strong Base Anion Resin Weak Acid Cation Resin
Weak Acid Cation Resin
Overview Weak Acid Cation Macroporous Weak Acid Cation Porous
Weak Base Anion Resin
Weak Base Anion Resin
Overview Weak Base Anion Gel Weak Base Anion Macroporous
Industries
Industries
Chemical Processing and Petrochemical Fine Chemicals
Fine Chemicals
Overview Cosmetics Fragrances
Food and Beverage
Food and Beverage
Overview Dairy Flavors Food Ingredients Fruit Juice
Fruit Juice
Overview Citrus Juice Debittering Patulin Removal Polyphenolic Compound Recovery
Gelatin and Collagen Organic Acid Purification Sugar
Sugar
Overview Beet Sugar Refining Cane Sugar Refining
Sweetener
Sweetener
Overview Corn Sweetener Refining
Additional Food and Beverage
Hydrometallurgy Metals Plating Oil & Gas Potable and Groundwater
Potable and Groundwater
Overview Arsenic Nitrate PFAS TOC, Bromide and DBP
Power
Power
Overview Fossil Nuclear
Pulp & Paper Semiconductor - Electronics
Applications
Applications
Adsorption Catalysis Condensate Polishing Demineralization Metal Removal and Recovery Organics Removal Softening

Healthcare & Life Sciences

With 40 years of manufacturing expertise and 30 years of regulatory experience, we supply leading separation, purification and extraction technologies to support chromatography and biocatalysis applications in healthcare and life sciences. 

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Pharmaceutical
Pharmaceutical
Overview APIs/Excipients Biocatalysis Milling Media Oligonucleotide Purification Peptide Purification Plasma Fractionation Radionuclide Separation
Medical Devices & Diagnostics
Medical Devices & Diagnostics
Overview Biofluid Treatment Diagnostics Enteral Nutrition
Nutraceuticals
Nutraceuticals
Overview Amino Acid Production Cannabinoid Purification Dairy Protein Isolation Protein Purification Supplement Ingredients Vitamin Purification
Analytical Lab Testing and Screening
Analytical Lab Testing and Screening
Overview Biocatalysis Screening Ligand Addition Protein Ion Exchange Chromatography Reference / Calibration Reversed Phase Chromatography

Purolite

We are the world leader in resin-based separation, purification and extraction technology, that provides sustainable solutions for our environment, businesses and healthcare.

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About
About
About Us
About Us
Overview History
Locations Services Manufacturing Customer Support Research & Development Brands
Brands
Chromalite™ CriticalResin™ LifeTech™ Macronet™ Microlite® Praesto® Purophase™ Purofine® Puromet™ Puromill™ Puropack® PuroSorb™ Shallow Shell™ UltraClean™
Environmental Commitment Careers
Resources
Resources
General Information Certifications
Certifications
Product Certifications Quality, Environment, Health and Safety
Terms of Sale Glossary and Definitions Case Studies
News & Events
News & Events
News Events Blog Webinars
Tools
Tools
Purolite Resin System Modeling (PRSM™) Unit Conversion Calculator
Overview
Literature

Principal Applications

  • Protein purification (20-500 kDa)
  • MAb Purification

Advantages

  • Excellent dynamic binding capacities for high-productivity and scalability
  • Excellent pressure/flow performance
  • High resolution/selectivity
  • Excellent chemical and physical stability
  • Secure, validated supply and regulatory support

Regulatory Approvals

  • Manufactured under GMP conditions
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APPLICATION GUIDE

Praesto Ion Exchange Resins

Typical Physical & Chemical Characteristics:

Polymer Structure Highly cross linked agarose
Appearance Spherical beads
Functional Group Sulfopropyl
Chemical stability All commonly used aqueous buffers. 1M NaOH, 8M urea, 6M guanidine hydrochloride, 30% isopropanol and 70% ethanol
Avoid Oxidising agents, cationic detergents
Ionic capacity - medium 0.11 - 0.16 mmol H⁺/ml
Ionic capacity - resin 0.11 - 0.16 mmol/ml
Particle Size - µm 45 µm
Dynamic Binding Capacity (min.) - 6 minutes residence time 80 lgG/ml
Dynamic Binding Capacity (min.)- 3 minutes residence time 80 hlgG/ml
Pressure/flow (min.) - at 3 bar in a 2.6 x 20 cm column (pressure-packed at 4 bar) 200 cm/h
pH stability, CIP (short term) 3 - 14
pH stability, working range 4 - 13
Recommended Storage 4 - 30 °C
Recommended Storage 20% ethanol
Recommended Storage 0.2M sodium acetate