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DurA Cycle A50
Driving innovation and performance while
reducing cost of goods.

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mAb & protein purification
mAb & protein purification
Overview Products
Products
Affinity Chromatography Resins
Affinity Chromatography Resins
Overview Purolite DurA Cycle A50 Purolite Praesto™ 70 CH1 Purolite Praesto™ AP+80 Purolite Praesto™ Jetted A50 HipH Purolite Praesto™ Jetted A50
IEX Chromatography Resins
IEX Chromatography Resins
Overview Purolite Praesto™ Jetted SP Purolite Praesto™ Jetted Q
Jetting Technology Technical Support
Tools & Services
Tools & Services
Knowledge Hub Chromatography Column Packing Calculator Throughput and Productivity Calculator Field Application Services

Purification Technologies

As a global leader in resin technology, we develop and manufacture small beads that are used in the most regulated industries in the world to separate, remove or recover very specific elements and compounds.

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Product Types
Product Types
Adsorbents
Adsorbents
Overview Adsorbents for Enzyme Immobilization Adsorbents for Gases and Organic Vapors Adsorbents of Organic Pollutants Citrus Juice Debittering Corn Sweetener Refining Inorganic Salt Separation Using Adsorbents Patulin Removal Polyphenol Recovery
Catalyst Chelation Resins Chromatographic Separation Resins Inert Spacer Polymers Mixed Bed Resins
Mixed Bed Resins
Overview Mixed Bed Nuclear Mixed Bed Ultrapure Water
Shallow Shell™ Resins Strong Acid Cation Resin Strong Base Anion Resin Weak Acid Cation Resin
Weak Acid Cation Resin
Overview Weak Acid Cation Macroporous Weak Acid Cation Porous
Weak Base Anion Resin
Weak Base Anion Resin
Overview Weak Base Anion Gel Weak Base Anion Macroporous
Industries
Industries
Carbon Capture Chemical Processing and Petrochemical Food and Beverage
Food and Beverage
Overview Dairy Flavors Food Ingredients Fruit Juice
Fruit Juice
Overview Citrus Juice Debittering Patulin Removal Polyphenolic Compound Recovery
Gelatin and Collagen Organic Acid Purification Sugar
Sugar
Overview Beet Sugar Refining Cane Sugar Refining
Sweetener
Sweetener
Overview Corn Sweetener Refining
Additional Food and Beverage
Hydrometallurgy Metals Plating Microelectronics Oil and Gas Potable and Groundwater
Potable and Groundwater
Overview Arsenic Nitrate PFAS TOC, Bromide and DBP Perchlorate
Power
Power
Overview Fossil Nuclear Green Hydrogen
Pulp and Paper
Applications
Applications
Adsorption Catalysis Condensate Polishing Demineralization Metal Removal and Recovery Organics Removal Softening Water Purity Solutions

Pharma and Medical

With 40 years of manufacturing expertise and 30 years of regulatory experience, we supply leading separation, purification and extraction technologies to support chromatography applications within the Pharma and Medical space.

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Pharmaceutical
Pharmaceutical
Overview APIs/Excipients Milling Media
Medical Devices and Diagnostics
Medical Devices and Diagnostics
Overview Biofluid Treatment Diagnostics
Nutraceuticals
Nutraceuticals
Overview Dairy Protein Isolation Supplement Ingredients Vitamin Purification

Purolite Resins

We are a world leader in resin-based separation, purification and extraction technology, that provides sustainable solutions for our environment, businesses and healthcare.

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About
About
About Us
About Us
Overview History
Locations Services Manufacturing Customer Support Research and Development Brands
Brands
CriticalResin™ Macronet™ Microlite™ Purofine™ Puromet™ Puromill™ Puropack™ PuroSorb™ Shallow Shell™ UltraClean™
Environmental Commitment
Resources
Resources
General Information Certifications
Certifications
Product Certifications Quality, Environment, Health and Safety
Terms of Sale Glossary and Definitions Case Studies
News & Events
News & Events
News Blog Webinars
Tools
Tools
Purolite Resin System Modeling (PRSM™) Unit Conversion Calculator
Overview
Literature

Principal Applications

  • Protein purification (20-500 kDa)
  • MAb Purification

Advantages

  • Excellent dynamic binding capacities for high-productivity and scalability
  • Excellent pressure/flow performance
  • High resolution/selectivity
  • Excellent chemical and physical stability
  • Secure, validated supply and regulatory support

Regulatory Approvals

  • Manufactured under GMP conditions
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PRODUCT BROCHURE

Purolite Praesto SP/Q Data File

Typical Physical & Chemical Characteristics:

Matrix Cross-linked agarose
Functional group CH2N+C+(CH3)3
Ionic capacity - medium 0.09 - 0.18 mmol Cl⁻/ml
Average particle size (d50ᵥ), μm 65 µm
Flow velocity Up to 350 cm/h (20 x 20 cm) cm/h
Binding Capacity mg/mL Resin at 6’ Residence Time ≥ 60 mg BSA/ml
Operating pH Stability (Short Term) 2 - 14
Operating pH Stability (Long-Term) 2 - 12
Working Temperature 4 - 30 °C
Chemical stability All commonly used aqueous buffers. 1M NaOH, 8M urea, 6M guanidine hydrochloride, 30% isopropanol and 70% ethanol
Avoid Oxidising agents, anionic detergents
Recommended storage 20% ethanol at 4 – 30 °C