Bioprocessing

Accelerate your biologic drug development with Praesto® 
chromatography resins.

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Monoclonal antibody and recombinant protein purification
Monoclonal antibody and recombinant protein purification
Products
Products
Praesto® Jetted A50 HipH Praesto® Jetted A50
Jetting Technology Technical Support
Tools & Services
Tools & Services
Field Application Services Throughput & Productivity Calculator

Core Technologies

As a global leader in resin technology, we develop and manufacture small beads that are used in the most regulated industries in the world to separate, remove or recover very specific elements and compounds.

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Product Types
Product Types
Adsorbents
Adsorbents
Overview Adsorbents for Enzyme Immobilization Adsorbents for Gases and Organic Vapors Adsorbents of Organic Pollutants Citrus Juice Debittering Corn Sweetener Refining Inorganic Salt Separation Using Adsorbents Patulin Removal Polyphenol Recovery
Catalyst Chelation Resins Chromatographic Separation Resins Fine Mesh Resins Inert Spacer Polymers Mixed Bed Resins
Mixed Bed Resins
Overview Mixed Bed Nuclear Mixed Bed Ultrapure Water
Strong Acid Cation Resin Strong Base Anion Resin Weak Acid Cation Resin
Weak Acid Cation Resin
Overview Weak Acid Cation Macroporous Weak Acid Cation Porous
Weak Base Anion Resin
Weak Base Anion Resin
Overview Weak Base Anion Gel Weak Base Anion Macroporous
Industries
Industries
Chemical Processing and Petrochemical Food and Beverage
Food and Beverage
Overview Dairy Flavors Food Ingredients Fruit Juice
Fruit Juice
Overview Citrus Juice Debittering Patulin Removal Polyphenolic Compound Recovery
Gelatin and Collagen Organic Acid Purification Sugar
Sugar
Overview Beet Sugar Refining Cane Sugar Refining
Sweetener
Sweetener
Overview Corn Sweetener Refining
Additional Food and Beverage
Hydrometallurgy Metals Plating Microelectronics Oil and Gas Potable and Groundwater
Potable and Groundwater
Overview Arsenic Nitrate PFAS TOC, Bromide and DBP Perchlorate
Power
Power
Overview Fossil Nuclear
Pulp and Paper
Applications
Applications
Adsorption Catalysis Condensate Polishing Demineralization Metal Removal and Recovery Organics Removal Softening

Healthcare and Life Sciences

With 40 years of manufacturing expertise and 30 years of regulatory experience, we supply leading separation, purification and extraction technologies to support chromatography and biocatalysis applications in healthcare and life sciences. 

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Pharmaceutical
Pharmaceutical
Overview APIs/Excipients Milling Media
Medical Devices and Diagnostics
Medical Devices and Diagnostics
Overview Biofluid Treatment Diagnostics
Nutraceuticals
Nutraceuticals
Overview Dairy Protein Isolation Supplement Ingredients Vitamin Purification

Purolite

We are a world leader in resin-based separation, purification and extraction technology, that provides sustainable solutions for our environment, businesses and healthcare.

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About
About
About Us
About Us
Overview History
Locations Services Manufacturing Customer Support Research and Development Brands
Brands
CriticalResin™ Macronet™ Microlite® Purofine® Puromet™ Puromill™ Puropack® PuroSorb™ Shallow Shell™ UltraClean™
Environmental Commitment
Resources
Resources
General Information Certifications
Certifications
Product Certifications Quality, Environment, Health and Safety
Terms of Sale Glossary and Definitions Case Studies
News & Events
News & Events
News Events Blog Webinars
Tools
Tools
Purolite Resin System Modeling (PRSM™) Throughput and Productivity Calculator Unit Conversion Calculator
Overview

Principal Applications

  • Nanoparticle milling
  • Preparation of ultra-fine nanoparticles
  • Biological cell disruption
  • Improve solubility of small molecules

Advantages

  • Creates nanoparticles less than 100 nm
  • Ultra High Purity
  • Exceptional wear resistance
  • Minimizes contamination
  • Uniform particle size; prevents screen binding
  • Highly efficient
  • Autoclavable / steam sterilizable
  • Scalable
  • Low media density; enables high media loads and agitation speeds
  • Generates less heat than traditional media
  • Biologically inert; prevents chemical reactions and composition changes

Systems

  • AISI 316 stainless steel or other metal alloy agitator bead mills
  • High-speed dispersers
  • Homogenizers
  • Rotor-stators

Typical Physical & Chemical Characteristics:

Polymer Structure Gel polystyrene crosslinked with divinylbenzene
Appearance Non-aggregated spherical beads, white to off-white in color
< 150 µm (max.) 0.02 %
250 – 350 µm (min.) 95 %
Particle Size Range 450 - 550 µm
Specific Gravity 1.06
Bulk Density (approx.) 610 g/L
Loss on drying (max.) 0.5 %
Residual styrene (max.) 50 ppm
Residual divinylbenzene (max.) 50 ppm
Residual ethylvinylbenzene (max.) 50 ppm
Residual solvent – methanol (max.) 50 ppm
Impurities Heavy Metals (max.) 10 ppm
Total Aerobes < 10 cfu/g
Total Moulds < 10 cfu/g
Total Yeasts < 10 cfu/g
Escherichia coli Negative/ 10 g g
Salmonella species Negative/ 10 g g
Pseudomonas aeruginosa Negative/ 10 g g
Staphylococcus aureus Negative/ 10 g g
Bacterial endotoxin test (max.) 0.5 EU/g
Identification (FTIR) Conform to Standard