Clinical diagnostics covers a wide range of applications, such as removal and analysis of:
- Recreational drugs
- Metabolites from human fluids
This is usually achieved using a cartridge containing hydrophobic adsorbent resins, which target hydrophobic components in the blood such as those in the above list.
Adsorbent resins are ideal for capturing and extracting hydrophobic molecules due to their highly hydrophobic nature. To ensure reproducible quantification of target compounds, the resins must be cleaned to a high degree to avoid causing interference during measurements. This makes control of leachables a key feature when selecting a suitable adsorbent for diagnostics.
Purolite provides a range of adsorbents suitable for diagnostic applications, in full compliance with Resap (2004)3 and FDA regulations, and manufactured in ISO-accredited facilities.
An example of resin-based immunotherapy treatments for leukapheresis
Leukapheresis immunotherapy involves the selective removal of specific cells from blood by using adsorbents coupled with specific ligands. These resins are suitable for treatment of diseases such as:
Another emerging application of Leukapheresis Immunotherapy is the treatment of patients who are due to have organ transplants. Patients need to have immunoglobulins removed as these antibodies can lead to transplanted organs being rejected. This new treatment uses affinity ligands and is administered a few days prior to the operation. This procedure can improve life expectancy by as much as 30% in some cases.
Reversed Phase Chromatography