Purolite™ Praesto™ Jetted A50

Excellent Pressure Flow Properties

The uniform particle size and highly cross-linked agarose base bead provides increased surface area without severely impacting pressure flow properties. Purolite Jetted A50 has excellent flow properties, with up to 200 cm/h achievable in a standard mAb platform process. This has been verified in process scale columns.

Alkaline Stability

Sodium hydroxide exhibits high efficiency in removing bound proteins, nucleic acids, and lipids from bioprocess resins, alleviating the risk of fouling on heavily burdened Protein A columns. Purolite Jetted A50 is alkaline stable for over 100 hours of exposure to 0.1 M NaOH, and over 30 hours of exposure to 0.5 M NaOH.

Dynamic Binding Capacity

Purolite Jetted A50 exhibits high dynamic binding capacities for conventional monoclonal antibodies, up to 70 g/L at a 10-minute residence time. Patented Jetting technology, coupled with the latest Protein A technology, allows for high capacity at even low residence times. The resin is uniquely suited to address the demands of modern bioprocessing, from high-titre cell cultures to continuous chromatography formats.