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Purolite Praesto 70 CH1

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CH1 Affinity Resin


Recent years have seen the expansion of antibody variants used in the development of therapeutic treatments, including the use of bispecifics. However, traditional methods of purification have proven inefficient.


Part of the Purolite™ Affinity Resin Toolbox


Purolite Praesto 70 CH1 is a 70μm (micron) agarose-based affinity resin designed to purify specialized mAbs such as bispecifics and recombinant antibody fragments, and can be used when Fc or light-chain binding is not viable.


The Purolite Difference


Developed in partnership with Repligen, an industry leader and partner in life sciences, Purolite Praesto 70 CH1 provides high capacity and alkaline stability.
Manufactured using Purolite’s patented Jetting technology, Purolite Praesto 70 CH1 offers uniform beads to ensure quality and performance.

Features

Up to 2X capacity compared to established CH1 affinity resins

Highest clean-in-place (CIP) alkaline stability of any CH1 binding resin

Supports process efficiencies to reduce long-term cost of goods

Product Data

NaOH Stability

Relative binding capacity of Praesto 70 CH1 after 0.1 M NaOH exposure.

Praesto 70 CH1 offers improved caustic stability compared to established CH1 resins, allowing the adoption of standard 0.1M NaOH CIP protocols.
Dynamic Binding Capacity
Capacity data for an IgG1 subclass monoclonal antibody on Praesto 70 CH1 at 3, 4.8, 6, and 10-minute residence time.

Praesto 70 CH1 offers higher binding capacity than any established CH1 resin, delivering favorable process economics for bispecifics and fusion proteins.

Resources

Purolite Praesto 70 CH1 Datafile

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Laboratory Scale Column Packing Instructions

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Pilot Scale Column Packing Instructions

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Purolite Praesto 70 CH1 IFU

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Purolite Praesto™ 70 CH1

Typical Physical & Chemical Properties

Matrix

Highly cross-linked agarose

Dynamic binding capacity

40 g/L mAb (IgG1) Fab* at 6 minute residence time

Average Particle Size

70 µm

Pressure/flow specifications

400 cm/h at 1.8 bar (30 x 20 cm)

Distribuția granulometrică

> 95% between 43-122 µm

pH Stability (Working Range)

2 - 13

pH Stability, CIP (Short Term)

2 - 13

Recommended storage

2 - 8 °C in 20% ethanol

Related Products

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Purolite Praesto Jetted A50 HipH

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Purolite Praesto AP+80