Application Note

The Impact of Elution pH on Product Quality of Fc-Containing Proteins

Discover how elution pH impacts product quality in Fc-containing proteins with this in-depth scientific poster.

As the biopharmaceutical landscape evolves with increasingly diverse Fc-containing molecules, traditional purification methods are being pushed to their limits. This poster explores how Praesto™ Jetted A50 HipH resin enables milder elution conditions - up to pH 5 - without compromising yield, purity, or viral clearance.

What you'll learn:

1. How higher elution pH improves aggregate removal and reduces HCP and DNA contamination

2. Comparative performance of six leading Protein A resins across multiple molecule types

3. Real-world data on viral clearance, dynamic binding capacity, and pressure-flow characteristics

Whether you're optimizing mAb purification or tackling the challenges of bispecifics and Fc-fusions, this poster delivers actionable insights backed by rigorous experimentation.

Download now to see how you can elevate your downstream process with smarter resin selection.