eBook

Optimizing Downstream Chromatography: Reduce Costs and Maximize Efficiency

Unlock the full potential of your bioprocessing workflows with Purolite™ Resins engineered for high dynamic binding capacity, faster mass transfer, and superior host cell protein (HCP) clearance.

Downstream chromatography can account for up to 80% of biomanufacturing costs, with protein A capture steps being the most resource-intensive. Purolite™ Jetted A50 and A50 HipH resins are engineered to address this challenge through advanced Jetted bead technology that delivers high dynamic binding capacities at shorter residence times. These innovations enable reduced bed heights, faster cycle times, and lower buffer consumption - without compromising product purity. When combined with process intensification strategies such as variable flow loading, reduced column volumes, and single-use systems, Purolite™ Resins help bioprocessing teams streamline operations, cut costs, and improve sustainability.

Produced in partnership with GEN, download the eBook to explore how to:

- Implement process intensification in chromatography workflows
- Optimize bed height and column design for cost and productivity
- Leverage jetted resin technology for superior mass transfer
- Reduce host cell protein (HCP) levels and aggregation
- Apply cost-of-goods modeling to evaluate purification strategies
- Scale processes effectively while maintaining performance
- Improve cleaning efficiency and resin stability
- Enhance sustainability through smarter buffer and water use