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With 40 years of manufacturing expertise and 30 years of regulatory experience, we supply leading separation, purification and extraction technologies to support chromatography and biocatalysis applications in healthcare and life sciences.
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Protein A and Ion Exchange chromatography resins for optimum purity in downstream mAb bioprocessing.
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Monoclonal antibody (mAb) therapeutics are widely-used to treat ailments including cancer, rheumatoid arthritis, dementia and diabetes. Agarose-based chromatography resins are a vital technology for biopharmaceutical developers to obtain optimal purity in downstream mAb bioprocessing.
A Typical mAb Platform
The purification of commercially-available monoclonal antibodies (mAbs) on the market today is typically performed in three chromatography steps:
How do Protein and mAb Purification Resins Work?
Affinity chromatography is a method of separating proteins based on a highly specific, reversible interaction between an individual or group of proteins, and a suitable ligand (see selection table) attached to a chromatographic matrix.
Ion Exchange chromatography is used to separate molecules based on their net surface charge.
Anion exchange chromatography uses a positively charged ion exchange resin with an affinity for molecules having net negative surface charges.
Cation exchange chromatography uses a negatively charged ion exchange resin with an affinity for molecules having net positive surface charges.
Evaluation Kit - MAb or Protein Purification