Overview
How Jetting Works
Particle Size Distribution
Jetted Products

What is Jetting Technology

Jetting technology is a patented, continuous manufacturing process for producing chromatographic resin beads with a narrow, uniform particle size distribution. 

Purolite is the only resin supplier to manufacture process-scale volumes of copolymer and agarose resin beads with uniform particle sizes. The uniform resin beads provide a more consistent chromatographic process. 

Our non-solvent jetting produces a 100% yield versus the traditional batch emulsification method of resin manufacture, with results as low as 40% yield. 

Jetting is being utilized by leading biopharmaceutical developers all over the world to streamline their mAb processes.

Advantages:

  • Uniform partical size
  • Faster mass transfer kinetics, shorter processing time frames
  • Shorter lead times
  • No net clogging or expensive packing failures
  • Precise lot-to-lot reproducibility
  • Improved resolution, more concentrated elutions
  • Non-solvent = Greener manufacturing
  • Custom particle sizes (available on request)
Security of Supply
  • Dual-continent manufacture (UK and USA) in 2021
  • Industry-leading capacity
  • ISO-accredited facilities

How Jetting Works

Jetting technology operates with two different processes, depending on the particle size needed. The first Purolite jetting process – membrane or ‘can’ jetting – entails using a membrane with very small, discrete orifices, through which the polymer is passed. This device is capable of producing uniform particle size chromatographic resins from ~15 to 250 micron.  Cooled, and then hardened, the beads are then collected in a vessel.  The process can run continuously.

Subsequent process steps (cross-linking, derivatization) are similar to those for emulisified beads.

This process is unique to Purolite, and an innovation in the manufacture of agarose beads.  There are significant opportunities to adjust the process to account for variability in regards to incoming materials, to ensure a highly consistent product with respect to particle size distribution.

The second process, plate jetting, utilises a plate with many precisely engineered holes, through which the resin polymer is passed. Uniform particle size chromatographic resins of ~150 to >1,000 micron can be produced using this method.

Particle Size Distribution

Jetting technology produces a much tighter distribution of particles (UC < 1.3) than traditional batch wise emulsification technologies (UC < 1.9). The time-consuming screening step found in batch wise emulsification is not required in the Jetting process, greatly reducing lead times.

Jetted Products

Jetting technology is used to manufacture select products in our ranges of agarose and synthetic chromatography resins, including Praesto® Jetted A50Praesto® Jetted Q35Praesto® Jetted SP35 and Chromalite®.

How Jetting Works
Particle Size Distribution

Dr. Patrick Gilbert (R&D Manager) on Jetting technology