Jetting technology operates with two different processes, depending on the particle size needed. The first Purolite jetting process – membrane or ‘can’ jetting – entails using a membrane with very small, discrete orifices, through which the polymer is passed. This device is capable of producing uniform particle size chromatographic resins from ~15 to 250 micron.  Cooled, and then hardened, the beads are then collected in a vessel.  The process can run continuously.

Subsequent process steps (cross-linking, derivatization) are similar to those for emulisified beads.

This process is unique to Purolite, and an innovation in the manufacture of agarose beads.  There are significant opportunities to adjust the process to account for variability in regards to incoming materials, to ensure a highly consistent product with respect to particle size distribution.

The second process, plate jetting, utilises a plate with many precisely engineered holes, through which the resin polymer is passed. Uniform particle size chromatographic resins of ~150 to >1,000 micron can be produced using this method.

Jetting technology produces a much tighter distribution of particles (UC < 1.3) than traditional batch wise emulsification technologies (UC < 1.9). The time-consuming screening step found in batch wise emulsification is not required in the Jetting process, greatly reducing lead times.

Jetting technology is used to manufacture select products in our ranges of agarose and synthetic chromatography resins, including Praesto® Jetted A50, Praesto® Jetted Q35, Praesto® Jetted SP35 and Chromalite®.