Praesto Jetted SP35 is an agarose-based, strong acid cation exchange resin designed for biomolecule purification, including proteins, peptides and oligonucleotides.  It is manufactured using 'Jetting' - a new, patented method that produces agarose beads with a very narrow particle size distribution.

Purolite is the first agarose resin provider to produce process-scale volumes of uniform particle size beads.

Praesto® Ion Exchange Chromatography Resins - FAQs

Principal Applications

  • MAb Purification
  • Protein purification (20-500 kDa)


  • Uniform particle size
  • Enhanced productivity
  • High dynamic binding capacity
  • Enhanced pressure/flow performance
  • Manufactured with reduced environmental impact
  • Secure, validated supply and regulatory support

Regulatory Approvals

  • Manufactured under GMP conditions

Typical Packaging

  • Bulk Resin
  • Production-Scale OPUS® Columns
  • OPUS® Robocolumns®
  • OPUS® MiniChrom Columns
  • HT Columns

Typical Physical & Chemical Characteristics:

Matrix Cross-linked agarose
Functional Group CH2CH2CH2S03
Ionic Capacity, mmol/mL Resin 0.11-0.16
Average Particle Size (d50ᵥ), μm 35
Flow Velocity cm/h at 3 bar in a 2.6 x 20 cm Column (packed at 4 bar) > 150
Binding Capacity mg/mL Resin at 6’ Residence Time > 90 mg/ml lgG
Operating pH Stability (Short Term) pH 3-14
Operating pH Stability (Long-Term) pH 4-13
Working Temperature 4-30°C
Chemical stability All commonly used aqueous buffers, 1M NaOH, 8M urea, 6M guanidine hydrochloride, 30% isopropanol and 70% ethanol
Avoid Oxidizing agents, cationic detergents
Storage 20% ethanol, 0.2M sodium acetate, 4-30°C