Praesto® AP Plus has been created to meet the industry demand for high productivity of clinical trial materials. This agarose-based resin has been purposely designed for the production of late-phase clinical trial material and commercial manufacture where multiple reuse cycles are required.

Principal Applications

  • Protein purification (up to 250 kDa)
  • MAb Purification


  • High productivity
  • Alkaline stable
  • Ultra-high dynamic binding capacity
  • Enhanced pressure/flow performance
  • Low protein A leaching
  • Secure, validated supply and regulatory support

Regulatory Approvals

  • Manufactured under GMP conditions

Typical Packaging

  • Bulk Resin
  • Production-Scale OPUS® Columns
  • OPUS® MiniChrom Columns
  • OPUS® Robocolumns®
  • HT Columns

Typical Physical & Chemical Characteristics:

Polymer Structure Highly cross linked agarose
Appearance Spherical beads
Functional Group Protein A
Particle Size - µm 85 µm
Dynamic Binding Capacity (min.)- 3 minutes residence time 35 hlgG/ml
Pressure/flow (min.) - at 3 bar in a 2.6 x 20 cm column (pressure-packed at 4 bar) > 700 cm/h
pH stability, CIP (short term) 2 - 12
pH stability, working range 3 - 10
Recommended Storage 2 - 8 °C
Recommended Storage 20% ethanol