Praesto AP is a Protein-A resin designed on a novel, high-flow agarose backbone, which addresses today s late stage clinical manufacturing challenges for high productivity, together with cost effective MAb capture. It is purpose-designed and evaluated for the production of late-phase clinical trial material, PIII and commercial manufacture, where typically hundreds of reuse cycles are performed.


Principal Applications

  • Protein purification
  • MAb Purification


  • Improved productivity
  • High capacity
  • Excellent pressure/flow performance
  • NaOH CIP stability for up to 200 cycles
  • Secure, validated supply and regulatory support

Regulatory Approvals

  • Manufactured under cGMP conditions

Typical Physical & Chemical Characteristics:

Polymer Structure Highly cross linked agarose
Appearance Spherical beads
Functional Group Protein A
Particle Size - µm 85 µm
Dynamic Binding Capacity (min.)- 3 minutes residence time 35 hlgG/ml
Pressure/flow (min.) - at 3 bar in a 2.6 x 20 cm column (pressure-packed at 4 bar) 500 cm/h
pH stability, CIP (short term) 2 - 12
pH stability, working range 3 - 10
Recommended Storage 2 - 8 °C
Recommended Storage 20% ethanol