Resins for Solid Phase Peptide Synthesis

Solid-phase peptide synthesis (SPPS) allows for the chemical synthesis of peptides and small proteins. It results in high yields of pure products and works far more quickly than classical liquid-phase peptide synthesis.  It allows the rapid assembly of a peptide chain through successive reactions of amino acid derivatives on an insoluble porous support.

Polystyrene is the most common core resin used in solid phase peptide chemistry, due to its chemical stability, compatibility with the majority of organic solvents, cost and availability


PuroSynth™ supports for solid-phase peptide synthesis (SPPS) are made of polystyrene containing 1% divinylbenzene (DVB) as a crosslinking agent. This polystyrene resin is insoluble in all common solvents, it swells well in most organic solvents and is supplied as uniform spherical beads.

One of the key features of PuroSynth™ products is the narrow particle size distribution due to the unique manufacturing process. ‘Jetting’ - the Purolite® patented manufacturing process, allows the production of uniform particle size, with low uniformity coefficient and high productivity in a continuous mode. This enables a more economic and environmentally friendly (reduced waste) process, than classic batch emulsion polymerization.

SPPS Resins Products by Application