Purolite® manufacturing technology for mono-dispersed chromatographic resin beads
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Seeding is the manfacturing method of producing chromatographic resin beads that are mono-size and ultra-fine. The beads produced have a narrow particle size distribution and are usually between 5 - 50 μm in size, although in some cases seeding can be used to produce larger beads.
Polystyrene 'seeds' are first produced through dispersion polymerization of styrene in alcohols. These initial seeds are in the range of 1 - 5 µm.
'Seeds' can be grown in two ways depending on the physical properties required in the final product:
Non-porous beads are swelled with monomers only
Macroporous beads are swelled with a combination of monomers and porogens
As the beads produced are uniform in size this results in improved performance in areas such as: