What is Jetting?

Most agarose-based resins on the market are produced using Batch Emulsification technology, first utilized around 50 years ago. This produces a relatively wide particle size distribution.

'Jetting' is a Purolite-patented, continuous manufacturing process for producing chromatographic resin beads with a narrow, uniform particle size distribution. Praesto bioprocessing resins are the only uniform agarose resins available for enhanced mAb purification.

Having a narrow particle size distribution is an advantage because it offers improved performance characteristics and more reproducible results. In simple terms, the more uniform the resin beads, the more consistently the resin will perform throughout scale-up (How is particle size distribution calculated?).

Advantages of Jetting

Jetting is a more streamlined, efficient manufacturing method, which eliminates fine particles in your resin. This enables you to run your process at higher flow velocities, improves column packing efficiency and reproducibility, and improves resin lifetime. The process is also "greener", as it utilizes no solvents and eliminates agarose wastage, which can be as high as 40% in traditional manufacturing processes. 

For Protein A processes, Praesto Jetting technology can improve your productivity, reduce buffer consumption, shorten processing windows and improve cost efficiencies by as much as 80% (learn more).

Agarose Chromatography Resins Products by Application