For more than 30 years, Protein A affinity resins have been selected by biopharmaceutical developers for mAb purification.
Today, Protein A affinity chromatography continues to be the preferred method for commercial purification of antibodies due to its very high selectivity and robust resin performance over repeated purification cycles.
Praesto® Protein A resins deliver exceptional performance in terms of capacity, pressure flow and lifetime; whilst bioburden risks and cross-contamination in processes are managed more effectively due to the ability to use higher concentrations of sodium hydroxide.
Affinity chromatography is a method of separating proteins based on a highly specific, reversible interaction between an individual or group of proteins, and a suitable ligand attached to a chromatographic matrix
Offering high selectivity, resolution, and capacity in most protein purification schemes; affinity chromatography has the advantage of utilizing a protein's biological structure or function for purification. Consequently, purifications that would have been time consuming and complicated, can often be easily achieved with affinity chromatography.
Protein & MAb Purification