What Is Jetting?

Jetting is a continuous manufacturing process for producing chromatographic resin beads with a narrow particle size distribution. Purolite Life Sciences uses Jetting to produce both copolymer and agarose-based resins, and are the only resin supplier in the world with the ability to manufacture jetted agarose products.

Compared with traditional batch emulsion manufacturing methods, Purolite's Jetting process results in higher product yield with no need for screening - reducing waste and environmental impact substantially. Production of large batches (>1,000kg) is streamlined, reducing customer lead times. 

When compared to standard batch emulsion manufacturing methods, Jetting offers many advantages, including:

  • More consistent packing characteristics
  • Better kinetics
  • Improved resolution
  • Higher dynamic binding capacities
  • Increased efficiency & productivity 

Fig. 1 Continuous Membrane Jetting Technology

Jetting technology operates with two different processes, depending on the particle size needed. The first Purolite jetting process – membrane or ‘can’ jetting – entails using a membrane with very small, discrete orifices, through which the polymer is passed. This device is capable of producing uniform particle size chromatographic resins from ~15 to 250 micron.  Cooled, and then hardened, the beads are then collected in a vessel.  The process can run continuously.

Subsequent process steps (cross-linking, derivatization) are similar to those for emulisified beads.

This process is unique to Purolite, and an innovation in the manufacture of agarose beads.  There are significant opportunities to adjust the process to account for variability in regards to incoming materials, to ensure a highly consistent product with respect to particle size distribution.

The second process, plate jetting, utilises a plate with many precisely engineered holes, through which the resin polymer is passed. Uniform particle size chromatographic resins of ~150 to >1,000 micron can be produced using this method.

Jetting technology is used to manufacture select products in our ranges of agarose and synthetic chromatography resins, including Praesto® Jetted A50, Praesto® Jetted Q35, Praesto® Jetted SP35 and Chromalite®.

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Manufacturing Jetted Protein A Resins