Praesto Q65 is an agarose-based strong anion exchange resin. Praesto Q65 is designed for large scale biomolecule purification, including proteins, peptides and oligonucleotides. The particle size (65 µm) makes Praesto Q65 ideal for intermediate purification of protein.

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Principal Applications

  • Protein purification
  • MAb Purification

Advantages

  • Excellent dynamic binding capacities for high-productivity and scalability
  • Excellent pressure/flow performance
  • High resolution/selectivity
  • Excellent chemical and physical stability
  • Secure, validated supply and regulatory support

Regulatory Approvals

  • Manufactured under cGMP conditions

Typical Physical & Chemical Characteristics:

Polymer Structure Highly cross linked agarose
Appearance Spherical beads
Functional Group Quaternary amine
Chemical stability All commonly used aqueous buffers. 1M NaOH, 8M urea, 6M guanidine hydrochloride, 30% isopropanol and 70% ethanol
Avoid Oxidising agents, anionic detergents
Ionic capacity - resin 0.14 - 0.18 mmol/ml
Ionic capacity - medium 0.14 - 0.18 mmol Cl⁻/ml
Particle Size - µm 65 µm
Dynamic Binding Capacity (min.) - 6 minutes residence time 60 BSA/ml
Pressure/flow (min.) - at 3 bar in a 2.6 x 20 cm column (pressure-packed at 4 bar) 400 cm/h
pH stability, CIP (short term) 2 - 14
pH stability, working range 3 - 13
Recommended Storage 4 - 30 °C
Recommended Storage 20% ethanol