Praesto AC is a Protein A resin designed to address today's clinical manufacturing challenges for high productivity, cost-effective MAb capture. Praesto AC combines good capacity, excellent pressure/flow performance and NaOH CIP stability for up to 20 cycles, meeting the common requirements for production of materials for PI and PII clinical trials. Praesto AC can also be used in small scale MAb purification, purification of MAbs for diagnostics, in process development and in pre-clinical processes

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Principal Applications

  • Protein purification
  • MAb Purification

Advantages

  • Improved productivity
  • High capacity
  • Excellent pressure/flow performance
  • NaOH CIP stability for up to 20 cycles
  • Secure, validated supply and regulatory support

Regulatory Approvals

  • Manufactured under cGMP conditions

Typical Physical & Chemical Characteristics:

Polymer Structure Highly cross linked agarose
Appearance Spherical beads
Functional Group Protein A
Particle Size - µm 85 µm
Dynamic Binding Capacity (min.)- 3 minutes residence time 25 hlgG/ml
Pressure/flow (min.) - at 3 bar in a 2.6 x 20 cm column (pressure-packed at 4 bar) 500 cm/h
pH stability, CIP (short term) 2 - 12
pH stability, working range 3 - 10
Recommended Storage 2 - 8 °C
Recommended Storage 20% ethanol